How to use Corvalol and why. Corvalol: components, how it works, instructions for use, to whom it is indicated, contraindications
The drug "Corvalol" (indications for the use of this drug will be discussed a little further) is a sedative, calming drug. You will learn about the conditions under which it should be used and other information from the materials in the presented article.
Composition of the drug
This product is made on the basis of ethyl ester of alpha-bromoisovaleric acid, menthol and phenobarbital. As for the excipients, these include the following: beta-cyclodextrin, potato starch, tabletose, magnesium stearate and microcrystalline cellulose.
Release forms
Why is the drug "Corvalol" prescribed? Indications for the use of this remedy, its principle of action and side effects will be described in detail in the following sections of the article. Now we will talk about the forms in which this product is produced. In pharmacy chains, the medicine "Corvalol" can be purchased in the form of drops. In addition, this drug is sold in tablets for oral and sublingual use.
Pharmacological action
The drug "Corvalol" is a combination drug, the effect of which is determined by the properties of its constituent components. It has a reflex vasodilating (that is, dilates blood vessels), antispasmodic and calming effect, and also greatly improves the natural onset of sleep. To understand how the presented medication works, let’s consider the pharmacodynamics of its active components:
- Phenobarbital facilitates the onset of sleep, significantly enhances the sedative effect of other substances and helps reduce the excitability of the central nervous system.
- Ethyl ester of alpha-bromoisovaleric acid, similar to the effect of valerian, has an antispasmodic and sedative effect.
- Peppermint oil has an antispasmodic and reflex-vasodilating effect.
Physical properties of the drug
The drug "Corvalol" in the form of drops is available in dark glass jars with a dispenser attachment, inside of which there is a clear, colorless liquid in an amount of 25, 30 or 50 ml with a specific odor. As for a similar medication, but only in the form of white tablets, it is placed in a cardboard package of 20 pieces.
Medicine "Corvalol": indications for use
This drug is used as a vasodilator, sedative and antispasmodic in the following pathological conditions:
Contraindications to the use of the product
According to the instructions, the drug "Corvalol" is not recommended for use in cases of abnormalities such as severe liver and kidney failure, during lactation and in cases of hypersensitivity to the active ingredients of the drug.
Instructions for use of the drug
The soothing medication Corvalol should be taken orally before meals in the amount of 15-30 drops three times a day. Before direct use, this drug must be dissolved in 30-50 ml of ordinary drinking water. According to the instructions, a single dose of this remedy for vascular spasms and tachycardia can be increased to 30-40 drops. The medicine "Corvalol" for children is usually prescribed in the amount of 3-15 drops per 3 large spoons of cooled boiling water. The duration of treatment with this drug in each individual case is determined individually and only by the attending physician. Regarding medicine in tablets, it should be taken 1 or 2 pieces before meals three times a day. For tachycardia, this drug can be taken in an amount of 3 pieces at a time.
Use with caution
This product should be used with extreme caution in the following cases:
- during the period of bearing a child;
- while driving a vehicle;
- when operating any mechanisms;
- during activities that require concentration and reaction speed.
Other uses
Many representatives of the fair sex use the drug “Corvalol” for acne. To do this, you need to soak a cotton pad in the medicine and then wipe the affected areas of the skin. Due to the fact that the product contains essential oils, it helps reduce inflammation and kill existing bacteria. After such treatment, you must wait until the medicine is completely absorbed, and then apply a soft and moisturizing cream to the skin.
Side effects
The use of Corvalol in some patients may cause a decrease in heart rate, dizziness, allergic reactions, drowsiness and loss of concentration. Long-term therapy with this drug (especially in large doses) quite often leads to addiction, bromism, dependence and withdrawal syndrome.
Drug overdose
If you exceed the prescribed dose of this drug, the patient may experience symptoms of depression nervous system. In addition, an overdose of Corvalol threatens to reduce blood pressure, ataxia, nystagmus, chronic bromine poisoning, as well as rhinitis, hemorrhagic diathesis, depression, impaired motor coordination, apathy and the appearance of conjunctivitis. In such cases, the patient is prescribed symptomatic therapy. When the nervous system is depressed, Caffeine and Niketamide are prescribed.
Popularity of the product
Due to its availability and low cost, the drug Corvalol (indications for use were described above) is actively used as an anti-anxiety and sedative. Very often it is prescribed to patients with depressive disorders. But when used regularly in large doses, such a medication can cause serious cognitive and neurological disorders (for example, short-term memory disorder, unsteady gait, speech impairment, etc.), as well as suppress sexual function. Pharmaceutical product Corvalol causes withdrawal symptoms and tolerance. In such cases, the patient must be referred to a psychiatrist and narcologist. IN medical practice There have been situations when a patient was hospitalized in the toxicology department with phenobarbital poisoning (when taking 125 ml of the drug for 3 days).
General information about the drug
The drug "Corvalol" is practically unknown and is not used outside of the country former USSR And Eastern Europe. However, in some Western European countries its German analogue, Valocordin, is available to consumers. It should be especially noted that in some countries the active components of this drug are classified as drugs that are prohibited for sale and import. In particular, the drug “Corvalol” is strictly prohibited from being transported to the United States of America and Lithuania. In Poland, there is a similar drug “Milocardin”, with phenobarbital included in it. In accordance with Government Decree No. 681 Russian Federation dated June 30, 1998, this component is included in the list psychotropic substances. As you know, their turnover in our country is limited.
A drug that has a complex effect on the body, sedative (calming), vasodilator and antispasmodic, is Corvalol. The instructions for use note it as a remedy that helps alleviate a person’s condition in case of sudden heart problems that arise against the background of a disorder of the nervous system and stress.
Release form
Corvalol is available in the form of drops in dropper bottles of 15 ml, 25 ml and 50 ml, and round tablets of white or almost white 10, 30, 50 pieces per package.
The drops contain:
- alpha-bromoisovaleric acid ethyl ester – 2%;
- phenobarbital – about 2%;
- peppermint oil – 1.14%.
Auxiliary components:
- caustic soda (sodium hydroxide);
- alcohol-water mixture - ethyl alcohol and distilled water.
1 tablet contains:
- alphabromisiovaleric acid ethyl ester – 8.2 mg;
- phenobarbital – 7.5 mg;
- peppermint oil – 0.58 mg.
Auxiliary components in tablets:
- beta-cyclodextrin – 55.6 mg;
- potato starch – 13 mg;
- lactose monohydrate – 43.8 mg;
- microcrystalline cellulose – 10.5 mg,
- magnesium stearate – 0.9 mg.
Pharmacological properties and effect of the drug
The main effect of the medication is aimed at reducing excitation processes in the central nervous system, eliminating muscle spasms on the walls of blood vessels, making it easier to fall asleep. Therefore, the drug is mainly used for functional disorders of the nervous and cardiovascular systems. As part of complex therapy, Corvalol can be used as an adjuvant for various diseases heart, blood vessels, gastrointestinal tract.
The pharmacological properties of Corvalol depend on the active substances that are included in its composition:
- Ethyl ester of alpha-bromoisovaleric acid, in addition to its calming effect, relieves spasms of the smooth muscles of blood vessels and internal organs.
- Phenobarbital has a hypnotic effect. In minimal dosage it acts as a mild sedative, slightly dilating the blood vessels.
- Peppermint oil, acting on certain receptors, dilates blood vessels and even has choleretic effect. It is a mild anti-inflammatory and antispasmodic agent.
Indications for use
At present, filled with stressful situations, the primary medicine that is present in every home is Corvalol. Indications for the use of this sedative are as follows:
- irritability;
- vegetative lability;
- insomnia;
- hypochondriacal syndrome;
- functional nervous disorders.
As a vasodilator, the drug is used in complex therapy for:
- atherosclerosis;
- cardialgia;
- sinus tachycardia;
- coronary heart disease;
- arterial hypertension.
The antispasmodic properties of this remedy help with:
- vegetative-vascular dystonia,
- diseases of the digestive system accompanied by spasms (intestinal and biliary colic).
How to take
Adults take Corvalol half an hour before meals, 15 to 30 drops diluted in a small amount (50 ml) of water. The same number of drops can be applied to a piece of sugar and taken in this form 2-3 times a day. If the cause of concern is associated with a strong heartbeat (tachycardia), then you can increase the dosage by taking 40-50 drops.
Tablets are taken orally, 1-2 pieces 2-3 times a day, with water or sublingually (under the tongue). For tachycardia, you can take 3 tablets at a time.
When taking the medicine sublingually, its absorption begins in the sublingual area and the positive effect appears almost instantly.
The period of use of the drug is determined by the doctor, based on the data of the clinical effect and individual tolerability of the drug.
Corvalol for children
Doctors do not have a consensus on this matter. Some doctors believe that children can be given from 3 to 15 drops per day, but only on the advice of the attending physician.
Others argue that Corvalol is not prescribed to children under 18 years of age.
Special instructions
Alcohol is prohibited while using Corvalol.
Most people tolerate this drug well, but taking it long time not recommended, due to a decrease in the therapeutic effect upon addiction, and at high doses in combination with long-term use, drug dependence may occur, which can cause withdrawal syndrome when discontinued.
It should also be borne in mind that the combined use of the drug with other medications with a calming effect significantly enhances its effect.
The drug should be taken with caution in case of arterial hypotension.
Pregnancy and lactation
When breastfeeding a child, the medication is prohibited, but if a decision is made in favor of using Corvalol, then it is necessary to stop breastfeeding for this period.
The drug is contraindicated during pregnancy. If necessary and in consultation with your doctor, you can use soothing herbal teas or medications such as Novo-Passit or Persen.
Contraindications
This sedative should not be taken in case of severe liver and kidney failure, glucose-galactose malabsorption, lactose intolerance, hypersensitivity to its components, pregnant women and nursing mothers (see above).
Interaction with other medications:
- the effect of Corvalol is enhanced by drugs of a central inhibitory type of action;
- the main active ingredient phenobarbital increases the activity of liver enzymes, and therefore simultaneous use of Corvalol with drugs that undergo biochemical transformations in the liver (for example, oral contraception, griseofulvins, drugs with coumarin derivatives, GCS);
- the described drug can enhance the effect of taking sleeping pills and painkillers (due to the content of barbituric acid derivatives in Corvalol);
- Corvalol enhances the effects of Valproic acid (an anticonvulsant);
- when taking Corvalol together with the antitumor drug Methotrexate, its toxicity increases;
- alcohol increases the toxicity of the drug and enhances its effects.
Side effects and overdose
The drug is well tolerated by most people, but negative reactions from the body still occur when taking Corvalol. Instructions for use indicate that slight dizziness, decreased concentration, a feeling of drowsiness, short-term diarrhea, and skin allergies may occur.
But excessive use of the medicine (overdose) can cause serious harm to health. The fact is that Corvalol contains a bromine-containing substance, which, when taken frequently, causes the accumulation of bromine in the body and the corresponding symptoms: apathy, depression, lacrimation, impaired motor coordination, rhinitis, conjunctivitis. Symptoms of overdose include: depression of the central nervous system, nystagmus (oscillatory eye movements with high frequency), ataxia (impaired motor skills), decreased blood pressure, agitation, dizziness, weakness.
If symptoms of overdose occur, stop taking the drug, rinse the stomach, further treatment– symptomatic.
How to replace Corvalol - analogues
Analogues of the drug by mechanism of action include:
- Adonis-bromine;
- Barboval;
- Valecard-health;
- Valemidin;
- Valocordin;
- Valoserdin;
- Darvilol;
- Lily of the valley-valerian drops;
- Drops of lily of the valley-motherwort;
- Corvaldin;
- Corvaltab;
- Hawthorn tincture;
- Motherwort tincture
- Reladorm.
Structural analogues of the active substance: Corvalol-MFF.
Storage conditions and shelf life
The drug must be stored out of the reach of children, protected from light, at a temperature of 15 to 25°C.
The shelf life is 2.5 years, it must be indicated on the label. After the expiration date, the medicine cannot be taken.
Available in pharmacies without a prescription.
Corvalol is a sedative that has been proven over the years and suppresses stress, nervousness, and anxiety. When used correctly, it will always help you survive the hardships of modern life. Be healthy!
Latest update of the description by the manufacturer 17.06.2009
Filterable list
Active ingredient:
ATX
Pharmacological group
3D images
Composition and release form
in dark glass dropper bottles of 15 or 25 ml; in a cardboard pack there is 1 dropper bottle.
Description of the dosage form
Transparent colorless liquid with a fragrant specific odor.
Characteristic
Combined drug.
Pharmacological action
Pharmacological action- antispasmodic, vasodilator, sedative.Pharmacodynamics
Phenobarbital has a sedative and mild hypnotic effect. Helps reduce central nervous system excitation and facilitate the onset of natural sleep. Ethyl bromizovalerate has a sedative and antispasmodic effect. Peppermint oil has reflex vasodilator and antispasmodic activity.
Indications for the drug Corvalol
As a sedative and vasodilator:
functional disorders cardiovascular system;
neurosis-like conditions accompanied by increased irritability;
sleep disturbances;
tachycardia;
states of excitement with pronounced vegetative manifestations.
As an antispasmodic:
intestinal spasms.
Contraindications
hypersensitivity to the components of the drug;
severe renal and/or liver dysfunction.
Prescription of the drug during pregnancy is possible only under strict indications. If it is necessary to prescribe the drug during breastfeeding, the issue of stopping breastfeeding should be decided.
Side effects
Corvalol is generally well tolerated. In some cases, drowsiness and slight dizziness may occur during the daytime.
With long-term use of large doses, the development of chronic bromine poisoning is possible, the manifestations of which include: depressive mood, apathy, rhinitis, conjunctivitis, hemorrhagic diathesis, and loss of coordination.
Directions for use and doses
Inside. The dosage is determined individually. Adults are usually prescribed 15-30 drops 3 times a day before meals. For tachycardia, it is possible to increase the single dose to 40-50 drops. Children are prescribed 3-15 drops per day depending on age and clinical picture diseases.
The duration of use of the drug is determined individually by the doctor.
Special instructions
The drug contains 79 volume percent ethanol and phenobarbital, therefore patients taking Corvalol are not recommended to engage in activities associated with increased attention and requiring rapid mental and motor reactions.
With prolonged use of the drug, the formation of drug dependence is possible; it is possible to accumulate bromine in the body and develop poisoning with it.
If any side (unusual) effects occur, you should report them to your doctor.
Storage conditions for the drug Corvalol
At a temperature not exceeding 25 °C.Keep out of the reach of children.
Shelf life of the drug Corvalol
5 years.Do not use after the expiration date stated on the package.
Instructions for medical use
Corvalol
Instructions for medical use - RU No. LP-003881
Last modified date: 05.10.2016
Dosage form
Pills.
Compound
Composition per tablet:
Ethyl bromizovalerate – 8.2 mg
(alpha-bromoisovaleric acid ethyl ester)
Phenobarbital – 7.5 mg
Peppermint leaf oil – 0.58 mg
Excipients:
β-cyclodextrin – 55.55 mg
Potato starch – 13.00 mg
Lactose monohydrate – 43.77 mg
Microcrystalline cellulose – 10.50 mg
Magnesium stearate – 0.90 mg
Description of the dosage form
Tablets are white or almost white with inclusions, round in shape with a flat surface, beveled to the edge with chamfers.
Pharmacological group
Sedative.
Pharmacodynamics
The combined drug has a sedative and antispasmodic effect, facilitating the onset of natural sleep.
Ethyl bromizovalerianate (ethyl ester of alpha-bromoisovaleric acid) has a sedative (similar to the effect of valerian) and antispasmodic effect due to irritation, mainly of receptors in the oral cavity and nasopharynx, a decrease in reflex excitability in the central parts of the nervous system and increased inhibition in the neurons of the cortex and subcortical structures of the brain, as well as a decrease in the activity of central vasomotor centers and a direct local antispasmodic effect on smooth muscles.
Phenobarbital has a sedative (in small doses), hypnotic, muscle relaxant and antispasmodic effects, helps reduce excitation of the central nervous system (CNS) and facilitates the onset of sleep, and enhances the sedative effect of other components.
Peppermint leaf oil has a reflex vasodilating effect. antispasmodic, mild choleretic, antiseptic effect. The mechanism of action is associated with the ability to irritate the “cold” receptors of the oral mucosa and reflexively dilate mainly the vessels of the heart and brain. Eliminates flatulence by irritating receptors in the mucous membrane of the gastrointestinal tract (GIT). enhancing intestinal motility.
Pharmacokinetics
Data on the pharmacokinetics of ethyl bromoisovalerate and the components of peppermint are not available. When taken orally, phenobarbital is absorbed slowly and completely. The maximum concentration in the blood plasma is determined after 1-2 hours. The connection with plasma proteins is 50%, in newborns - 30-40%. Metabolized in the liver, induces microsomal liver enzymes with isoenzymes CYP3A4, CYP3A5, CYP3A7 (the rate of enzymatic reactions increases 10-12 times). Cumulates in the body. The half-life is 2-4 days. Excreted by the kidneys in the form of glucuronide, about 25% unchanged. Penetrates into breast milk and through the placental barrier.
Indications
Corvalol is prescribed as a symptomatic (sedative and vasodilator) agent for functional disorders of the cardiovascular system. in neurosis-like conditions, accompanied by increased irritability, difficulty falling asleep, tachycardia, a state of excitement with pronounced vegetative manifestations; as an antispasmodic for intestinal spasms.
Contraindications
- Hypersensitivity to the components of the drug;
- Severe renal and/or liver dysfunction;
- Pregnancy;
- Breastfeeding period;
- Children under 18 years of age (efficacy and safety have not been established);
- Lactase deficiency, lactose intolerance, glucose-galactose malabsorption (the drug contains lactose).
With caution
Impaired kidney and/or liver function.
If you have one of the listed diseases/conditions, be sure to consult your doctor before taking the drug.
Use during pregnancy and breastfeeding
The use of the drug Corvalol during pregnancy and breastfeeding is contraindicated, since the drug contains phenobarbital, which penetrates the placenta and has a teratogenic effect, has a negative effect on the formation and further functioning of the central nervous system of the fetus and newborn; penetrates into breast milk, the development of physical dependence in the newborn is possible. If it is necessary to use the drug during breastfeeding, the issue of stopping breastfeeding with breast milk should be decided.
Directions for use and doses
For oral administration, before taking, write with water.
Adults are usually prescribed 1-2 tablets of the drug 2 times a day.
For tachycardia, it is possible to increase the single dose to 3 tablets.
The maximum daily dose is 6 tablets.
The dosage and duration of treatment is determined by the doctor individually for each patient.
Side effects
Corvalol is generally well tolerated. In some cases, drowsiness, slight dizziness, slow heart rate, decreased ability to concentrate, and an allergic reaction may occur. Gastrointestinal disturbances may occur. These phenomena disappear when the dose of the drug is reduced or the drug is stopped.
With prolonged use of the drug, the formation of drug dependence, addiction, “withdrawal” syndrome, as well as the accumulation of bromine in the body and the development of bromism phenomena (depressive mood, apathy, rhinitis, conjunctivitis, hemorrhagic diathesis, impaired coordination of movements) is possible.
If any of the side effects listed in the instructions get worse, or you notice any other side effects not listed in the instructions, tell your doctor.
Overdose
Symptoms: depression of the central nervous system, nystagmus, ataxia, decreased blood pressure, agitation, dizziness, weakness, chronic bromine intoxication (depression, apathy, rhinitis, conjunctivitis, hemorrhagic diathesis, impaired coordination of movements).
Treatment: stopping the drug, gastric lavage and symptomatic therapy, for central nervous system depression - caffeine, niketamide.
Interaction
Medicines that depress the central nervous system enhance the effect of the drug.
Phenobarbital (an inducer of microsomal oxidation) may reduce the effectiveness of drugs metabolized in the liver (including coumarin derivatives, griseofulvin, glucocorticosteroids, oral contraceptives); enhances the effect of local anesthetics, analgesics and hypnotics.
The drug increases the toxicity of methotrexate.
The effect of the drug is enhanced by the use of valproic acid drugs.
Special instructions
There is no experience with the use of the drug in children under 18 years of age.
You should not drink alcohol while using the drug.
Effect on ability to drive vehicles, mechanisms.
The drug contains phenobarbital, so patients taking Corvalol should refrain from driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
Release form
Pills.
10, 20 or 25 tablets in a blister pack (blister) made of polyvinyl chloride film and printed varnished aluminum foil.
1, 2, 3, 4, 5 or 10 blisters, together with instructions for medical use, are placed in a cardboard pack.
30, 50, 100 blisters, along with an equal number of instructions for medical use, are placed in a cardboard box (for hospitals).
Storage conditions
In a place protected from light, at a temperature not exceeding 25°C.
Keep out of the reach of children.
Best before date
2 years. Do not use after expiration date.
Conditions for dispensing from pharmacies
Over the counter.
LP-002745 dated 2015-05-26
Corvalol - instructions for medical use - RU No. R N000123/01 dated 2007-07-12
Corvalol - instructions for medical use - RU No. R N000444/01 dated 2012-11-20
Corvalol - instructions for medical use - RU No. LSR-001750/09 dated 2017-06-30
Corvalol - instructions for medical use - RU No. R N000426/01 dated 2012-04-25
Corvalol - instructions for medical use - RU No. R N002085/01 dated 2012-09-11
Corvalol - instructions for medical use - RU No. LS-002249 dated 2015-01-13
Corvalol - instructions for medical use - RU No. LP-003881 dated 2016-10-05
Corvalol - instructions for medical use - RU No. R N001855/01 dated 2013-11-25
Synonyms of nosological groups
| Category ICD-10 | Synonyms of diseases according to ICD-10 |
|---|---|
| F48.9 Neurotic disorder, unspecified | Secondary neurotic symptom |
| Other neurotic conditions | |
| Neurosis | |
| Neuroses | |
| Neuroses of all kinds | |
| Neuroses with retardation | |
| Neuroses of the heart | |
| Neurotic disorders in alcoholism | |
| Neurotic disorders with retardation | |
| Neurotic disorders with anxiety syndrome | |
| Neurotic reactions | |
| Neurotic symptoms in alcoholism | |
| Neurotic conditions | |
| Neurotic syndrome | |
| Neurotic disorder | |
| Attack of neurological dysfunction | |
| School neurosis | |
| Emotional stress | |
| G47.0 Disturbances in falling asleep and maintaining sleep [insomnia] | Insomnia |
| Insomnia, especially difficulty falling asleep | |
| Desynchronosis | |
| Long-term sleep disturbance | |
| Difficulty falling asleep | |
| Difficulty falling asleep | |
| Difficulty falling asleep | |
| Insomnia | |
| Short-term and transient sleep disturbances | |
| Short-term and chronic sleep disorders | |
| Short or shallow sleep | |
| Sleep disturbance | |
| Sleep disturbance, especially during the falling asleep phase | |
| Sleep disorders | |
| Sleep disorders | |
| Neurotic sleep disorder | |
| Shallow, shallow sleep | |
| Shallow sleep | |
| Poor sleep quality | |
| Night awakening | |
| Night awakenings | |
| Sleep pathology | |
| Postsomnia disorder | |
| Transient insomnia | |
| Problems falling asleep | |
| Early awakening | |
| Early morning awakening | |
| Early awakenings | |
| Sleep disorder | |
| Sleep disorder | |
| Persistent insomnia | |
| Difficulty falling asleep | |
| Difficulty falling asleep | |
| Difficulty falling asleep in children | |
| Difficulty falling asleep | |
| Difficulty falling asleep | |
| Persistent insomnia | |
| Deterioration of sleep | |
| Chronic insomnia | |
| Frequent night and/or early morning awakenings | |
| Frequent awakenings at night and a feeling of shallow sleep | |
| I99 Other and unspecified circulatory system disorders | Angiopathy |
| Arterial angiopathy | |
| Atherosclerotic angiopathy | |
| Age-related vascular diseases | |
| Hemodynamic defects of the right half of the heart | |
| Hemodynamic defect of the right half of the heart | |
| Ischemic angiopathy | |
| Arterial circulation disorder | |
| Circulatory disorders | |
| Violation of microcirculation in organs and tissues | |
| Peripheral circulation disorders | |
| Peripheral circulation disorders in the extremities | |
| Circulatory failure | |
| Occlusive hemodynamic disorder of arteriovenous origin | |
| Acute circulatory failure | |
| Pseudoanginal conditions | |
| Pseudoanginal disorder | |
| Circulatory disorder | |
| Risk of blood clots | |
| Cardiovascular diseases | |
| Vascular insufficiency | |
| Thrombosis of arteriovenous shunt | |
| Thrombosis during heart valve replacement | |
| Poor circulation in the pelvic organs | |
| Functional failure of the cardiovascular system | |
| Functional disorders of the cardiovascular system | |
| Chronic arterial insufficiency | |
| Chronic circulatory failure | |
| R00.0 Tachycardia, unspecified | Tachycardia |
| R45.1 Restlessness and agitation | Agitation |
| Anxiety | |
| Explosive excitability | |
| Internal excitement | |
| Excitability | |
| Excitation | |
| Excitement is acute | |
| Psychomotor agitation | |
| Hyperexcitability | |
| Motor excitement | |
| Relief of psychomotor agitation | |
| Nervous excitement | |
| Restlessness | |
| Night restlessness | |
| Acute stage of schizophrenia with agitation | |
| Acute mental agitation | |
| Paroxysm of excitement | |
| Overexcitement | |
| Increased excitability | |
| Increased nervous excitability | |
| Increased emotional and cardiac excitability | |
| Increased arousal | |
| Mental excitement | |
| Psychomotor agitation | |
| Psychomotor agitation | |
| Psychomotor agitation | |
| Psychomotor agitation in psychosis | |
| Psychomotor agitation of an epileptic nature | |
| Psychomotor paroxysm | |
| Psychomotor seizure | |
| Symptoms of arousal | |
| Symptoms of psychomotor agitation | |
| State of agitation | |
| State of anxiety | |
| State of excitement | |
| A state of heightened anxiety | |
| State of psychomotor agitation | |
| States of anxiety | |
| States of arousal | |
| States of excitement in somatic diseases | |
| State of excitement | |
| Feeling restless | |
| Emotional excitement | |
| R45.4 Irritability and anger | Outbursts of anger |
| Anger | |
| Dysphoria | |
| Neurosis with increased irritability | |
| Bitterness | |
| Increased irritability | |
| Increased irritability of the nervous system | |
| Irritability | |
| Irritability with neuroses | |
| Irritability in psychopathic disorders | |
| Symptoms of irritability |
Corvalol is a popular remedy that is probably found in every home medicine cabinet. The use of Corvalol is not limited to cardiac and nervous disorders, it is used as an antispasmodic and antiviral external agent, but is it as safe and harmless as it seems at first glance?
Corvalol: myths and reality
A serious debate has recently developed around the usual “home” remedy: phenobarbital, which is the main active ingredient of the drug, is included in the list of narcotic and psychotropic substances.
You can find many articles claiming that Corvalol is a dangerous drug that causes severe dependence, withdrawal syndrome and threatens physical and mental health state. What are the dangers of long-term use of the drug and to whom is it contraindicated?
Composition of the drug and release form
In addition to the already mentioned phenobarbital, Corvalol contains bromoisovaleric acid ester and essential oil peppermint. Together, these substances have a depressing and inhibitory effect on the nervous system.
- Corvalol drops are available in the form of an alcohol solution and are packaged in dark glass bottles. Content ethyl alcohol– no less than 47%. The drops have a specific odor and taste bitter.
- the drug in tablets contains the same active ingredients as the drops, but does not include ethanol.
Indications for use
The use of the drug is determined by the effect it has:
- sedative
- antispasmodic
- sleeping pills
- Bromoisovaleric acid ester:
- reduces reflex excitability of parts of the nervous system;
- enhances inhibition in neurons of the cerebral cortex;
- reduces the activity of vasomotor centers
- Phenobarbital:
- reduces neuron excitability;
- improves sleep, promotes falling asleep;
- has an antispasmodic effect on the gastrointestinal tract;
- has a pronounced anticonvulsant effect;
- slows down the conduction of nerve impulses
- Peppermint oil contains menthol and has:
- mild sedative effect
- choleretic effect
- antiseptic and antispasmodic effect.
Taken together, the drug has an effect on large vessels and smooth muscles, therefore it is used for high blood pressure as part of complex therapy, in case of rhythm disturbances - tachycardia, arrhythmia.
Taking Corvalol is especially important for high blood pressure caused by stress, anxiety, and negative emotions. Corvalol is used as a sleeping pill and a mild tranquilizer.
Directions for use and dosage
It should be noted right away that Corvalol is prescribed for short-term use in courses, both in the case of nervous and mental disorders, and in case of sleep disorders.
- Corvalol drops are taken regardless of food, 2-3 times a day. A single dose in most cases is 15-30 drops. The tincture is diluted in ¼ cup of warm boiled water, or dripped onto a piece of refined sugar. In the latter case, the availability of the drug and the rate of absorption increase significantly.
- To normalize sleep, it is enough to take Corvalol once a day, drinking 30 drops at night.
- with high blood pressure, the single dose can be increased to 45 drops, but in this case it is better to use special hypertensive drugs.
- Corvalol tablets are taken as a sedative, 1-2 tablets 3 times a day, on an empty stomach, with a sufficient amount of water.
Contraindications
The instructions for use of the drug stipulate cases in which Corvalol is contraindicated:
- During pregnancy and lactation. In some cases, nursing mothers are prescribed the drug in tablets, but similar recommendations for breastfeeding should be given by a doctor, correlating possible risk and potential benefits. There are a number modern drugs, which have a sedative and hypnotic effect and are approved for pregnant and lactating women, if necessary, it is worth considering the possibility of using them, eliminating the risk to the mother and fetus. It is not recommended to prescribe alcohol tinctures, including due to the effects of ethanol, while bromine tends to accumulate in the body, threatening possible poisoning.
- In case of hypersensitivity to the components of the drug;
- For severe pathologies of the kidneys, liver, cardiovascular system;
- For brain diseases, traumatic brain injuries;
- Children under 3 years old. At an older age and in adolescents, the drug is prescribed by a doctor strictly according to indications in short courses, in each specific case individually.
Despite the fact that phenobarbital has antiepileptic activity, an alcohol solution of Corvalol is not prescribed to relieve convulsions and seizures due to the harmful effects of ethanol.
People whose work requires increased attention and reaction and who spend a lot of time behind the wheel should take alcohol preparations with caution.
Corvalol with alcohol
With a hangover, feeling all the “joys” of alcohol intoxication, a person strives to normalize the condition with the help. The main symptoms of intoxication intensify after binge drinking:
- headache, dizziness;
- weakness, apathy, absent-mindedness and memory;
- nervousness, irritability;
- thirst, dry mouth;
- hand tremors, heart rhythm disturbances, ;
- increased sweating, nausea, vomiting
At first glance, Corvalol relieves most of the listed symptoms, helping to stabilize the condition. However, in fact, taking Corvalol after alcohol or together with it causes serious harm to the body:
- by stimulating the synthesis of liver enzymes, Corvalol promotes rapid absorption of ethanol breakdown products into the blood, worsening intoxication;
- liver cells directly involved in the processing and removal of decay products are under attack;
- the vessels have the opposite effect, a sharp expansion-constriction changes blood pressure, which leads to bradycardia;
- respiratory centers are depressed, the risk of death during sleep increases;
- impact on gastrointestinal tract provokes the development of gastritis, loose stools, flatulence, and dyspepsia.
The choice in favor of Corvalol as an anti-hangover drug is erroneous and dangerous; both the drunk and the hangover need help of a different kind. You can die from Corvalol as a result of a combination of ethanol and the components of the drug, as well as with the wrong dosage, which can happen with a high probability of a hangover.
Corvalol for diabetes
Patients with diabetes mellitus often complain of pain in the heart area - the disease is characterized by complications from the cardiovascular system.
In the list of contraindications for Corvalol, however, diabetes mellitus is listed as a contraindication for understandable reasons.
Phenobarbital, which is part of the drug, suppresses the production of the glucocorticoid hormone cortisol (it is synthesized by the adrenal cortex), which leads to a sharp decrease in blood glucose levels.
Hypoglycemia is manifested by absent-mindedness, nausea, weakness, dizziness, and in severe cases it can provoke coma and death. That is why taking Corvalol when diabetes mellitus contraindicated and requires strict control of blood sugar levels.
Is it possible to take Corvalol at fever
There is an opinion that Corvalol should be taken when high temperature body to “unload” the heart and blood vessels suffering from overheating. Moreover, similar method It is also practiced in pediatrics, the dosage depends on the age of the child - 1 drop per 1 year of life.
But since sufficient clinical trials have not been conducted, it is worth consulting with your doctor before taking such measures.
The roots of this treatment go back to the distant past, when the choice of antipyretic and cardiac drugs was not great. Today, you can choose safe and effective products for both adults and children.
Corvalol for low blood pressure
With low blood pressure and a low pulse, it is not recommended to take Corvalol, since it further reduces the pressure, which leads to severe hypotension, weakness, impaired consciousness and heart rhythm, bradycardia, depression of cardiac and respiratory activity.
Use for herpes
Cauterization with Corvalol helps dry out the rashes and promotes their speedy healing.
The duration of treatment of rashes is 2-3 days, targeted, in the absence of an individual reaction to the drug.
Compatibility with other drugs
- Corvalol enhances the effect of sedatives, hypnotics and cardiac drugs;
- combination with drugs that are metabolized by the liver (contraceptive, hormonal, steroid drugs, antibiotics) is not advisable.
You can take it with Corvalol if you need to urgently calm down and pull yourself together, but this medication intake should be short, the duration of treatment is 7-10 days. The drugs enhance each other's effects.
Corvalol and afobazole have a similar effect on the body. The dosage should be calculated individually, since a sharp decrease in blood pressure and heart rate is possible.
Side effects
Taking the drug may cause unwanted side effects:
- CNS - impaired consciousness, increased arousal, motor disorder, nightmares, nervousness, insomnia, sleep disturbances, hallucinations, irritability, anxiety, headaches;
- Respiratory system– depression of the respiratory centers, apnea;
- Cardiovascular system – bradycardia, arrhythmia, arterial hypotension;
- Digestive system– vomiting, nausea, stool disorders;
- Allergic reactions;
- Bromine intoxication: you can be poisoned by Corvalol due to the accumulation of bromine in the body.
Considering all of the above, we can say with confidence that you cannot drink Corvalol every day; treatment is carried out in short courses with a precisely maintained dosage of the drug.
Despite numerous positive reviews about the use of Corvalol, including in pediatrics, the modern pharmacological industry offers a number of safe and effective drugs, the selection and prescription of which should be carried out by a specialist.
The components that make up Corvalol eliminate disorders of the human nervous system. They also facilitate the process of falling asleep naturally. And they even help against some heart diseases.
Release form and composition
The company that produces Corvalol produces drops in black glass with a volume of less than 50 ml. The product is also sold in tablets, which are stored in plates. One holds 10 pieces.
The medicine contains the following elements:
Active substances: phenobarbital – 18.26 mg, ethyl ester of alpha-bromoisovaleric acid – 20 mg;
Auxiliary components: peppermint oil, ethanol 95%, artesian water, sodium hydroxide.
How Corvalol works
Helps in cases of spreading spasm and irritability.
The elements contained in the medication perform sedative functions:
- Phenobarbital. Nerve impulses stop traveling to the brain. Vital energy gradually decreases, reactions become more passive. Within a short period of time, the calming process begins. The pressure decreases, but does not relieve the symptoms of hypertension. This component reduces bilirubin levels and helps with Gilbert's syndrome;
- Oil from mint components. Dilates blood vessels, fights bloating. When consumed, a minty taste is felt;
- Ethyl ester of "alpha-bromoisovaleric acid". The processes of excitation cease, and calmness gradually occurs. The “inhibition” of the personality begins.
Indications for use
Prescribed to reduce nervousness. Helps with negative emotions and poor natural sleep. The use of Corvalol is effective against manifestations of hypertension, stomach and intestinal pain.
Contraindications
Instructions for use of Corvalol
If there is an increase in heart rate - three times a day. At serious illnesses– increase to six techniques.
If you use the medicine and then drink alcohol, the effect of Corvalol will not occur.
On the contrary, the heart rate accelerates from alcohol and decreases from the drug. The first is eliminated quite quickly and a sharp contraction of blood vessels occurs.
Overdose in most cases leads to serious consequences. Starting from inflammatory skin lesions to unstable heart function. As a result internal organs do not receive enough oxygen and essential vital substances. Depression and neuropsychiatric disorders appear. And then death may occur. Take Corvalol taking into account the contraindications.
Side effects
It is well tolerated by patients if you follow the rules of use and do not increase the dose. In the case where a person has a high sensitivity to the drug, then possible following symptoms- vomiting, indigestion, dizziness.
In the worst cases, spasms of the limbs, exhaustion, and lethargy occur. The heart rate also decreases and heart beats gradually decrease.
Corvalol during pregnancy
Pregnant women may experience sleep disturbances. Increased nervousness is possible. Hormonal disorders during fetal development are a common symptom. The use of Corvalol can be dangerous for a child due to one component - phenobarbital. Therefore, it is better not to take the drug.
Pharmacological experts have studied that frequent use of the drug has a very bad effect on the mother and fetus. Substances enter the stomach and therefore the child also receives them.
If you wake up in the middle of the night due to lack of air and cannot cope without the help of medications, then it is better to take valerian and validol. They will be able to relieve symptoms. But, if dependence on the medicine manifests itself, then it is better to use panangin and verapamil. They contain elements that do not harm the health of mother and child.
Constant use of the medication can lead to serious consequences, because the chemical compounds are harmful.
Before deciding to take any drug, it is recommended to consult a gynecologist.
Drug analogues
Many analogues of the drug have appeared on the market. Pharmacological studies have revealed similar medications, which are not inferior to Corvalol in functionality. At the same time, they do not contain harmful substances.
Valerian– reduces nervousness, dilates coronary vessels, reduces the number of heart beats, a person falls asleep easily. The components of the medication enhance the effect of the medications taken for spasm and sedation.
Valocordin– removes symptoms of tachycardia, high irritability and fear. Eliminates problems with falling asleep.
Verapamil– from sudden angina and fluctuations in heart beats, arrhythmia.
Barboval– relieves neuroses, excitability, insomnia, hysteria. Taken for mild attacks of angina, spasms of the stomach and intestines.
Corvaldin– helps with fear, excitement, nervous system disorders, anxiety, and makes it easier to fall asleep. The components included in the medication are very well tolerated. Harmless to the heart, even if it functions in a poor rhythm. The number of strokes gradually decreases and eventually returns to normal.
Korvaltab– eliminates high nervousness. Doctors can prescribe it for insomnia. Prevents cardiovascular system disorders, spasms, initial stages sudden increase and decrease in pressure.
Motherwort tincture– a sedative, normalizes the heartbeat. Eliminates harmful substances, inflammation. Acts as a mild diuretic.
